Basic Information
VIS ID
TVIS30014596
Fusion event
HIV-chr1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
158322490/158352700 (Hg38)
End
158322343/158352700 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/1416456; hsa-mir-1182/Downstream/1547279;
Nearest TSS
ENST00000473358/Upstream/21169; ENST00000464822/Downstream/996;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/170987, chr1-CpG: 44/Downstream/818712
Nearby gene
CD1E(No orient, 995)
Upstream sequence
AGCACAGAAAGAGTATTGAAAATAAATGTAGATATTCTACTCAGGAAACAAGGAAACTTTTTATCTTTCTTTTAACTTAGAATTTAGAAATGATAATAAG
Downstream sequence
ATGAAACTAGGTTTGGACCTTTTTCAATAATTCTGACCACCGTTCAGTAAATTTACTGTATAAGAAAAGTAGAGGTTTGGGGTTGAATTTTGTTTTATTT
Target sequence
agtgtaaaagtgttcctatttctccacatcctctccagcacctCTCCAGCACAGAAAGAGTATTGAAAATAAATGTAGATATTCTACTCAGGAAACAAGGAAACTTTTTATCTTTCTTTTAACTTAGAATTTAGAAATGATAATAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate