Basic Information
VIS ID
TVIS30014600
Fusion event
HIV-NDUFS2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
161175189/161205399 (Hg38)
End
161175067/161205399 (Hg38)
Orient
-
Location type
Intronic
Target gene
NDUFS2
miRNAs that regulate target gene
hsa-mir-940 ; hsa-let-7a-5p ; hsa-mir-8485 ; hsa-mir-3180-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1305320; hsa-mir-1182/Downstream/21787;
Nearest TSS
ENST00000473358/Upstream/3023; ENST00000473321/Downstream/1010;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/2933, chr1-CpG: 54/Downstream/53288
Upstream sequence
ACTACCCCCTACTTTGTCCCAGTACTAATCATCCCTCTCTTAGGAAGTCCCAATAAGAGTTCCATGGATGTTTActtccttgtttctaagatttggccca
Downstream sequence
tgttgatttcatagcctggaatgcttcttctcccttctagctatctaaatcatttcctatatttgagctcagatcctacctacatgaagtcttTGCAGTG
Target sequence
GATATGTACAGATAATTGAACCACTACCCCCTACTTTGTCCCAGTACTAATCATCCCTCTCTTAGGAAGTCCCAATAAGAGTTCCATGGATGTTTActtccttgtttctaagatttggccca
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate