Basic Information
VIS ID
TVIS30014609
Fusion event
HIV-TSEN15 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
184038325/184069191 (Hg38)
End
184038441/184069191 (Hg38)
Orient
+
Location type
Intronic
Target gene
TSEN15
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-let-7b-5p ; hsa-mir-449a
Nearest miRNA
hsa-mir-101-1/Upstream/3630801; hsa-mir-1182/Downstream/8647137;
Nearest TSS
ENST00000473358/Upstream/14830; ENST00000645316/Downstream/49851;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/17271, chr1-CpG: 113/Downstream/317090
Upstream sequence
AATAGTGTTAACTGTGTATTTGCTTCAGGCTTGTTTTCAAGTTAGCTATATGAAGCTCTGGAATCACTTTTTTTCAGTACACAGAGCTCCTCTATGAACA
Downstream sequence
GTTTAAAACTTGAAACTGTTAGTATTAATACATAGGTTATATTTTTCATAGGTTGATTTCTATCCAATATGAACTATAAAGAATTTTATCGTTTATTGTT
Target sequence
GTTATGAGAAATAAAAACCTGTTGTGAGCATCAAATTTTGTTGCTGTTATTAAATAGCTATTATTATTGATACATATTTTTCTTTAGGTGGGATTTTTCCCTTTAGATATAACTGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate