Basic Information
VIS ID
TVIS30014611
Fusion event
HIV-UCHL5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
192998382/193029252 (Hg38)
End
192998262/193029252 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA1K
Target gene
UCHL5
miRNAs that regulate target gene
hsa-mir-5581-3p ; hsa-mir-657 ; hsa-mir-3665 ; hsa-mir-3185 ; hsa-mir-6872-3p ; hsa-mir-1322 ; hsa-mir-9500 ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-5584-5p ; hsa-mir-2681-5p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-6883-3p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-454-5p ; hsa-mir-6512-5p ; hsa-mir-1-5p
Nearest miRNA
hsa-mir-101-1/Upstream/312862; hsa-mir-1182/Downstream/107251;
Nearest TSS
ENST00000473358/Upstream/5312; ENST00000469214/Downstream/57;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/220184, chr1-CpG: 94/Downstream/29839
Upstream sequence
AATATCAGGAACAGGAACTGCATTACCTAAATCAATCGGTCCTTCTCTTAATCCATCTAATTCATACAGTCTCCCATTAACAGGAACATAACTGACAAAG
Downstream sequence
TGAAAAGCATCTTCTTCTTTTGCTGATGTCTTCGTATCAAATTCAAACATTTGCTGTCTACAGTAAATAAAAAAATAGTGAAACTCAAAGAAGCAAAGAA
Target sequence
TTTTCCCCTGTCAAAAGTGAAATATCAGGAACAGGAACTGCATTACCTAAATCAATCGGTCCTTCTCTTAATCCATCTAATTCATACAGTCTCCCATTAACAGGAACATAACTGACAAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate