Basic Information
VIS ID
TVIS30014613
Fusion event
HIV-chr1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
194485604/194516474 (Hg38)
End
194485665/194516474 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/1379891; hsa-mir-1182/Downstream/2065939;
Nearest TSS
ENST00000473358/Upstream/165531; ENST00000496761/Downstream/1544599;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1394380, chr1-CpG: 24/Downstream/2092104
Nearby gene
CDC73(No orient, 1261662)
Nearest cancer related gene
CDC73(TSG, No orient, 1261662)
Upstream sequence
ACTTCTGTCATTTTTTGACTTGTACATCACATTAATATAACTAATGCTCTGACTTAAATAATGTTCATATTTTCACTGTTGAAAAGTTGTCCCACATTAA
Downstream sequence
GACTAGGAACTAAGAATCTAGAATCCTGAATTTCGCTACCTGAGCTTTAATTTAAATTCAGAGTGGCTATTCTTTAGCCAATAGCATAAGAATCCCAGAC
Target sequence
ATGACTAATATCTCATTACGAATATAGAAAATTGCCTTTTGTGAAGTTATGAGCCCTCAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate