Basic Information
VIS ID
TVIS30014616
Fusion event
HIV-DENND1B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
197564955/197595825 (Hg38)
End
197564842/197595825 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
DENND1B
miRNAs that regulate target gene
hsa-mir-6869-5p ; hsa-mir-155-5p ; hsa-mir-4312 ; hsa-mir-532-5p ; hsa-mir-802 ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-195-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1013344; hsa-mir-1182/Downstream/1263048;
Nearest TSS
ENST00000473358/Upstream/49052; ENST00000440885/Downstream/62525;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/394236, chr1-CpG: 103/Downstream/178976
Upstream sequence
GTCCTCCAGGATCACTTACCATTTAATTTTATTTTTGGAAGTCTCATTTGCATATATAATTTTCCAGTCATTTGTTGAATAGTTTTTGTCATTATGAGAT
Downstream sequence
AAAGAAGAGGGGAGAAGAGATAAAGTTATTGAAATTATACCATGAGTGGAGAATTTTATGCAAATGTTatacattgtgtcatttaatcttcaccacagtc
Target sequence
TTATTTGTTACAGGTCCTCCAGGATCACTTACCATTTAATTTTATTTTTGGAAGTCTCATTTGCATATATAATTTTCCAGTCATTTGTTGAATAGTTTTTGTCATTATGAGAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate