Basic Information
VIS ID
TVIS30014619
Fusion event
HIV-ATP6V1G3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
198506789/198537659 (Hg38)
End
198506647/198537659 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
ATP6V1G3
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-377-3p ; hsa-mir-891a-3p ; hsa-mir-342-3p ; hsa-mir-1228-3p ; hsa-mir-6865-5p ; hsa-mir-6815-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-570-3p ; hsa-mir-4635 ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1955178; hsa-mir-1182/Downstream/321214;
Nearest TSS
ENST00000473358/Upstream/259955; ENST00000367364/Downstream/3015;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/378425, chr1-CpG: 36/Downstream/1497687
Upstream sequence
TGACTTCTTGGTCCTCATTCTGAATATCATTCTGCCTTAATATGTCAGAATTTCAAATGAATCTTTGTATGAAAAAATAAAGCAAAAGTATATGGGTTTA
Downstream sequence
CTAAAATGATAACTATCTTTACCTCTCCTGTCATCATGCCTCCTTTCCCTTTTTAAAATAGTCATTtgtgcatttatctcactgggaagttctttaagga
Target sequence
GAGAAAATGACCATAGACCTTCTACAATGGTGTTCACTATTGTGACTTCTTGGTCCTCATTCTGAATATCATTCTGCCTTAATATGTCAGAATTTCAAATGAATCTTTGTATGAAAAAATAAAGCAAAAGTATATGGGTTTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate