Basic Information
VIS ID
TVIS30014641
Fusion event
HIV-NEK2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
211838371/211665029 (Hg38)
End
211838232/211665029 (Hg38)
Orient
-
Location type
Intronic
Target gene
NEK2
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-92a-3p ; hsa-mir-1279 ; hsa-mir-186-5p ; hsa-mir-4652-3p ; hsa-mir-4668-5p ; hsa-mir-4778-5p
Nearest miRNA
hsa-mir-101-1/Upstream/2041519; hsa-mir-1182/Downstream/412584;
Nearest TSS
ENST00000473358/Upstream/22162; ENST00000415202/Downstream/4490;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/85194, chr1-CpG: 43/Downstream/10270
Upstream sequence
tcggcttaagtgatcttcctgcctgagccccagagtagctgggactataggtgcgtcaccacacttggcTCTTAATGGGACAGTTTTATAAGAAAGAAAG
Downstream sequence
TGTTTTAAAAACATTTTTAAAATTCTTCCATTAAATAGAAGAATGAATATTTCATCAAATACGAAAAGAACAGCTTTTAAAAAAGACACTGCTGCTTGCT
Target sequence
tcacaggtgcagctgtagtgcactacagccttggacgcctcggcttaagtgatcttcctgcctgagccccagagtagctgggactataggtgcgtcaccacacttggcTCTTAATGGGACAGTTTTATAAGAAAGAAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate