Basic Information
VIS ID
TVIS30014643
Fusion event
HIV-NSL1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
212928395/212755053 (Hg38)
End
212928481/212755053 (Hg38)
Orient
+
Location type
Intronic
Target gene
NSL1
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-26b-5p ; hsa-mir-146a-5p ; hsa-mir-146b-5p ; hsa-mir-181b-2-3p ; hsa-mir-181b-3p ; hsa-mir-3129-3p ; hsa-mir-410-3p ; hsa-mir-4420 ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-4531 ; hsa-mir-4735-5p ; hsa-mir-5583-5p ; hsa-mir-5703 ; hsa-mir-653-3p ; hsa-mir-7153-5p
Nearest miRNA
hsa-mir-101-1/Upstream/677368; hsa-mir-1182/Downstream/7362800;
Nearest TSS
ENST00000473358/Upstream/55068; ENST00000532433/Downstream/36528;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/54347, chr1-CpG: 45/Downstream/36471
Upstream sequence
CCAGCCTGGGATTGTTTGGGGCCAGATGGAAGGCAACCAAACCTACTAGACAGAGGGAGTGAAAGCAGTGGTAGACAGATATGCACATGAAAAATTCTAG
Downstream sequence
AGGAATTTACTGCAGATGAAATGAAAATAGAGCAATATAAAAATGACTTTAAAATGCTACACAGCTCCAATAGCTAAAGAAAATCATAAGACATTGCAAA
Target sequence
TCAAGAAGCACTTGCAAATCAAAAGTCTAAAATACATGAAGAAATTAAAACCATGAAAGACAGCCAGTATAACCAATGTCAGGGAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate