Basic Information
VIS ID
TVIS30014645
Fusion event
HIV-RRP15 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
218476558/218303216 (Hg38)
End
218476519/218303216 (Hg38)
Orient
-
Location type
Intronic
Target gene
RRP15
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-221-5p ; hsa-mir-3672 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4461 ; hsa-mir-4768-3p ; hsa-mir-4786-5p ; hsa-mir-4793-5p ; hsa-mir-5186 ; hsa-mir-6502-3p ; hsa-mir-6864-3p ; hsa-mir-6888-5p ; hsa-mir-769-5p ; hsa-mir-8073
Nearest miRNA
hsa-mir-101-1/Upstream/6225531; hsa-mir-1182/Downstream/1814637;
Nearest TSS
ENST00000473358/Upstream/17874; ENST00000488793/Downstream/42462;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/17874, chr1-CpG: 57/Downstream/42499
Upstream sequence
GTTGTACATAAATTTGTGGTTTATTATAAAAGCTAAAAATCCATGATAAGGCTTTCATATCACCTGTACTTGATGATCTCTGTCTAAAATACTTGGTTAC
Downstream sequence
TAAATTAAGCATGTTTTTTAATTAAAGAAAAATAACTTTCTACAAATGTACTGGCAGCATAGAAGTACTAATTCCCAAAGTCACTTCATAGGTAAAAATG
Target sequence
ACCTGTACTTGATGATCTCTGTCTAAAATACTTGGTTAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate