Basic Information
VIS ID
TVIS30014646
Fusion event
HIV-TP53BP2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
224026620/223838918 (Hg38)
End
224026560/223838918 (Hg38)
Orient
-
Location type
Intronic
Target gene
TP53BP2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-1301-3p ; hsa-mir-877-3p ; hsa-mir-222-3p ; hsa-mir-548d-3p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3638299; hsa-mir-1182/Downstream/418122;
Nearest TSS
ENST00000473358/Upstream/12849; ENST00000618397/Downstream/6876;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/89576, chr1-CpG: 138/Downstream/6465
Nearest cancer related gene
TP53BP2(TSG, No orient, 0)
Upstream sequence
TCCCTGCAGATGTGGAAGATCTGAGATCTCTATGGTAATATTAGATAGAGGTGGGAAGAAATAGCTATTGAGATGTTTCCTTTGCCCAGGGGGAGGTAAC
Downstream sequence
CACCTCCACATCATTTGAAAGTTGATAAGAGAACTATCTGCCAATCTTCTCATCAGTATGGATTTAAATAAGGGACGATGTCTCCAtttttttctttttt
Target sequence
TTAGATAGAGGTGGGAAGAAATAGCTATTGAGATGTTTCCTTTGCCCAGGGGGAGGTAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate