VISDB - VIS Detail

Basic Information

VIS ID

TVIS30014647

Fusion event

HIV-FBXO28 integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr1

Cytoband

q42.11

Reference genome

GRCh37/hg19

Start

224312720/224125018 (Hg38)

End

224312486/224125018 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA1H

Target gene

FBXO28

miRNAs that regulate target gene

hsa-mir-148b-3p ; hsa-mir-130b-3p ; hsa-mir-132-3p ; hsa-mir-221-3p ; hsa-mir-181a-5p ; hsa-mir-32-5p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-615-3p ; hsa-mir-17-5p ; hsa-mir-448 ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-19a-3p ; hsa-mir-208a-5p ; hsa-mir-130a-3p ; hsa-mir-9-3p ; hsa-mir-320a ; hsa-mir-301a-3p ; hsa-mir-504-3p ; hsa-mir-320b ; hsa-mir-320c ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-208b-5p ; hsa-mir-320d ; hsa-mir-3140-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-4429 ; hsa-mir-4698 ; hsa-mir-4433b-3p ; hsa-mir-8063 ; hsa-mir-210-5p ; hsa-mir-3607-3p ; hsa-mir-3976 ; hsa-mir-5000-5p ; hsa-mir-6769a-3p ; hsa-mir-885-5p ; hsa-mir-660-5p ; hsa-mir-5591-3p ; hsa-mir-455-5p ; hsa-mir-759 ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-567 ; hsa-mir-298 ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-606 ; hsa-mir-124-3p ; hsa-mir-506-3p ; hsa-mir-3682-5p ; hsa-mir-3688-3p ; hsa-mir-8084

Nearest miRNA

hsa-mir-101-1/Upstream/3924399; hsa-mir-1182/Downstream/132022;

Nearest TSS

ENST00000473358/Upstream/10800; ENST00000465848/Downstream/50738;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/10248, chr1-CpG: 130/Downstream/57865

Upstream sequence

ggtttcaccctgttgaccaggtggtcttgaactcctaacctcagctgatgcgcccAGCCGAAAGATGTATGATCTCTTGTGTTTTTGTGCTGTTGGTTAG

Downstream sequence

TCAGTGCTTCTTGAACATTTGAACATACAGGAAAACTACCACATTAAATACTGTTCTTTCCTTACAATATTGCCTAATGTTTAAAATAAtttttcttttt

Target sequence

agtggcgtgatcttggctcactgcaaccttcacctcaggttcaagcgaccctcctgcctcagcctcccaagtagctgggattacaggcgccggctaccatgcctggcaaatttttgtatttttagtagagatggggtttcaccctgttgaccaggtggtcttgaactcctaacctcagctgatgcgcccAGCCGAAAGATGTATGATCTCTTGTGTTTTTGTGCTGTTGGTTAG

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.