Basic Information
VIS ID
TVIS30014648
Fusion event
HIV-NVL integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.11
Reference genome
GRCh37/hg19
Start
224475382/224287680 (Hg38)
End
224475506/224287680 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
NVL
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-let-7b-5p ; hsa-mir-186-5p ; hsa-mir-138-5p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-101-1/Upstream/30570; hsa-mir-1182/Downstream/110547;
Nearest TSS
ENST00000473358/Upstream/17765; ENST00000477413/Downstream/6661;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/103627, chr1-CpG: 37/Downstream/42347
Upstream sequence
taaaCAAATCGGATCTCAAACAAAAGAAAAACCATTGTTGGGGGCTTGAAAGAAGTGCTACATTCAAGTCAAGTTAGACACAGTGATTATAGTCAAGTCA
Downstream sequence
GTCTTCCAGGGCACCAATATCTGCCCATGTCACATTAGGGACAGTGACAAAGCCTTCCCTTTTGGCAGAGGGTTGGACTGAGGATAGAGCAACAATGAAA
Target sequence
GTTTAGCCACAGAACCTAGTACACATGCATGGAGCTTTATCTCTGGTCTTTAATCCATGACATGCCAATAATATTTGGCAGCTGATATACCTACCAATATTGCCATGGTGAGCTCCTCTCTAAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate