Basic Information
VIS ID
TVIS30014651
Fusion event
HIV-chr1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.13
Reference genome
GRCh37/hg19
Start
229269033/229133286 (Hg38)
End
229269227/229133286 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
LOC105373158 ; LOC112267873
Nearest miRNA
hsa-mir-101-1/Upstream/671134; hsa-mir-1182/Downstream/1886542;
Nearest TSS
ENST00000473358/Upstream/38381; ENST00000323223/Downstream/94276;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/378082, chr1-CpG: 70/Downstream/137613
Nearby gene
RAB4A(No orient, 137845)
Upstream sequence
aatctttggggtctgttctaactccaggaagttagtgccaaaattgaatagcaatataccaattggggtcAGAATCGCTAGAAAAATAGGTTAGGTGGTG
Downstream sequence
CCTGAACAGGGAAACCTACCAAACTTCTCACCTCCCAGAGAAAATTGTGCCCTCACATGGAAGATGAGGAGAGCCTGCTCCTCTCATTCCAGCGGCTCTC
Target sequence
GACTTCACTGGGACATCCAGGCAGAGGTGGTGCCTTGGAATGAGGAAGTGGAGACAGAATGATATGAATAGGTGAGATCACTTCCACTGGAGTCCAAGCTAAGTCAGCTTCTTAAATCGTTCACATTCCCACCTCCTCACAGCCAAATGAGACCATTTCCTGCCCAGAGACTGGTTTCAGCTGGGCATCAATTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate