Basic Information
VIS ID
TVIS30014652
Fusion event
HIV-SPHAR integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.13
Reference genome
GRCh37/hg19
Start
229441247/229305500 (Hg38)
End
229441212/229305500 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA1H
Target gene
SPHAR
miRNAs that regulate target gene
hsa-mir-5089-5p ; hsa-mir-6807-5p ; hsa-mir-6866-5p ; hsa-mir-877-5p ; hsa-mir-6775-3p ; hsa-mir-1291 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-7976 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-1292-3p ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-125a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/843348; hsa-mir-1182/Downstream/1714328;
Nearest TSS
ENST00000473358/Upstream/643; ENST00000418348/Downstream/13903;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/34118, chr1-CpG: 129/Downstream/36662
Upstream sequence
AAGATAAATGTAAAGTTGTTTTATAAACGATCCTGTTAATTAAACCACAGACACCATATATCCTTCTGCATCCTTTGGCCAATAAAAGTTGCTGGAGAAC
Downstream sequence
CAAACCATGGTGGTTCTTAATCAGGCTTTGCCTTTAGGGAGAATGAGGAGGAGAGATAATTGGGTATTGTTCAGGCTAGTAATAAATGTCATGTTTCTAT
Target sequence
CTGCATCCTTTGGCCAATAAAAGTTGCTGGAGAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate