Basic Information
VIS ID
TVIS30014653
Fusion event
HIV-NUP133 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.13
Reference genome
GRCh37/hg19
Start
229604369/229468622 (Hg38)
End
229604321/229468622 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
NUP133
miRNAs that regulate target gene
hsa-mir-1301-3p ; hsa-mir-1303 ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-516b-5p ; hsa-mir-1289 ; hsa-mir-1298-3p ; hsa-mir-3126-3p ; hsa-mir-3120-3p ; hsa-mir-590-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1006470; hsa-mir-1182/Downstream/1551206;
Nearest TSS
ENST00000473358/Upstream/17552; ENST00000417605/Downstream/39704;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/33685, chr1-CpG: 57/Downstream/39344
Upstream sequence
CCAATCACATTTTTAGTTTTGCTGTATCATATTCCTAAAATATTATTCTATATGTATCCAACTGATAATTTCCAGACCCTTCTCCAATAATTCAGCTAAC
Downstream sequence
TGAAACATGTACATACACTAAATTGACACTTATACTTTGCCCTTTGATCCAAATGCAGAATAATGAACCAGGCTCTTGCTCAGTTCTTACAAGTAGTCTG
Target sequence
TGTATCCAACTGATAATTTCCAGACCCTTCTCCAATAATTCAGCTAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate