VISDB - VIS Detail

Basic Information

VIS ID

TVIS30014653

Fusion event

HIV-NUP133 integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr1

Cytoband

q42.13

Reference genome

GRCh37/hg19

Start

229604369/229468622 (Hg38)

End

229604321/229468622 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA1H

Target gene

NUP133

miRNAs that regulate target gene

hsa-mir-1301-3p ; hsa-mir-1303 ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-516b-5p ; hsa-mir-1289 ; hsa-mir-1298-3p ; hsa-mir-3126-3p ; hsa-mir-3120-3p ; hsa-mir-590-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p

Nearest miRNA

hsa-mir-101-1/Upstream/1006470; hsa-mir-1182/Downstream/1551206;

Nearest TSS

ENST00000473358/Upstream/17552; ENST00000417605/Downstream/39704;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/33685, chr1-CpG: 57/Downstream/39344

Upstream sequence

CCAATCACATTTTTAGTTTTGCTGTATCATATTCCTAAAATATTATTCTATATGTATCCAACTGATAATTTCCAGACCCTTCTCCAATAATTCAGCTAAC

Downstream sequence

TGAAACATGTACATACACTAAATTGACACTTATACTTTGCCCTTTGATCCAAATGCAGAATAATGAACCAGGCTCTTGCTCAGTTCTTACAAGTAGTCTG

Target sequence

TGTATCCAACTGATAATTTCCAGACCCTTCTCCAATAATTCAGCTAAC

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.