Basic Information
VIS ID
TVIS30014656
Fusion event
HIV-chr1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.13
Reference genome
GRCh37/hg19
Start
229890847/229755100 (Hg38)
End
229890981/229755100 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1H
Nearest miRNA
hsa-mir-101-1/Upstream/1292948; hsa-mir-1182/Downstream/1264728;
Nearest TSS
ENST00000473358/Upstream/104253; ENST00000445339/Downstream/130652;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/128548, chr1-CpG: 171/Downstream/311647
Nearby gene
URB2(No orient, 94901)
Upstream sequence
TCAGGGCACAATGACAAGGCTTTGATTGTCAACCACTGTAGCTGGCTCCAGCTTTGCTTGGCTTTGACAGATGAAAAGCCATTTTCCACATTGTAGGCCT
Downstream sequence
ACAGGATGTAGACAGGCGTCTAAATAATTCTAATTTCTCATTTTTTGGAAGAGGTATTTCCCAGTGAGCAAACATCAGTAGGGAAAGGCGAACTCTCGGG
Target sequence
GCTTCCTGTGGTTTCATCCAGTCCAGTGAGTATTCGGCCCTGTGATTGACACAACCTCAGAATGTGTATGCACCCCCAGAAGACTGTCGTCTGAAAGGAGGGGAATGTGGAAATATCAACAGTTATAGAAACCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate