Basic Information
VIS ID
TVIS30014659
Fusion event
HIV-chr1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.3
Reference genome
GRCh37/hg19
Start
234850415/234714668 (Hg38)
End
234850703/234714668 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1H
Nearest miRNA
hsa-mir-101-1/Upstream/408129; hsa-mir-1537/Downstream/475366;
Nearest TSS
ENST00000473358/Upstream/5285; ENST00000642107/Downstream/9374;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/103390, chr1-CpG: 30/Downstream/389571
Nearby gene
LINC01132(+9374) ;
Upstream sequence
TATCTTCTCCCTATCTCAaaaacaaaaaaacaaaacaaaacaaaacTTTAAAAATCCATGAAGCATTAGCTATTTTTAgaaattttaacttttctattat
Downstream sequence
GTTCACAAAGATAATTTTACTTCAAGATTTACAGTCGTGCCTCTCATCTAAAGCAATCTTCCTCACCCTCTCCCCGGCACTATTTCTCACCAGCCCTCAA
Target sequence
ctaacaatacatatttcctgagcattttaagtccattttaattttgtgtactatttaatggtaaatcgtggtatatatcctcaacataatacttcatatccttgcagtccgattattcagtcagccttcacttcttcagattaaacaatATAACTTCAATTTGCATATGTTCTCCAGGTTATTGCAAAATAAACCTGTTTCAGTGCATTTGAAGTATAGAACAGTGATCATTTTAAATCACACTCAATTGCCCAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate