Basic Information
VIS ID
TVIS30014660
Fusion event
HIV-ARID4B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.3
Reference genome
GRCh37/hg19
Start
235341884/235178569 (Hg38)
End
235342036/235178569 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
ARID4B
miRNAs that regulate target gene
hsa-mir-106a-5p ; hsa-mir-19b-3p ; hsa-mir-20b-5p ; hsa-mir-92a-3p ; hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-17-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4325 ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-17-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-302a-3p ; hsa-mir-302e ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-520a-3p ; hsa-mir-520b ; hsa-mir-302c-3p ; hsa-mir-520c-3p ; hsa-mir-302d-3p ; hsa-mir-520d-3p ; hsa-mir-520e ; hsa-mir-302b-3p ; hsa-mir-3691-3p ; hsa-mir-4480
Nearest miRNA
hsa-mir-101-1/Upstream/872030; hsa-mir-1537/Downstream/11465;
Nearest TSS
ENST00000473358/Upstream/2926; ENST00000489692/Downstream/3296;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/17167, chr1-CpG: 157/Downstream/148454
Upstream sequence
AACATAGTAGTTCTAAAAAACGTCTCATCTTCTTGGTGGGAAATTATTGCAAAACATTACAAATAAATGTCTCCCTTTTCTTCAAGGACTAGCCCAAGTC
Downstream sequence
TTCTCCAGAGACTAATAAAGTACTATCTCCATTCAGTTCCAATGTCAGACACCAAATCAACCTTCTGTGTATAAAACCTAACTTCCTTGATCAAAAACAG
Target sequence
CTACATCTTCACTAAGATGTTCCAGGCTTCACTGATCAATCACTACTCTGAACTGTAGCATTTTTCTATACTACTCATTTGGTCCTTAACATCTGCTATATTTCTGTCTAATTCATATATGTTATCTCTCAGACTATATAAAGTAAGATTTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate