Basic Information
VIS ID
TVIS30014661
Fusion event
HIV-LYST integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.3
Reference genome
GRCh37/hg19
Start
235903532/235740232 (Hg38)
End
235903489/235740232 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
LYST
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-93-5p ; hsa-mir-92b-3p ; hsa-mir-193a-3p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/550116; hsa-mir-1537/Downstream/112768;
Nearest TSS
ENST00000473358/Upstream/2225; ENST00000412098/Downstream/3800;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/89044, chr1-CpG: 113/Downstream/126055
Upstream sequence
GAAAGTGTCTTAATACTGGAAAAAGCACCTAAAAGTATTCCTTCCAGATAGTTTTGACTCCTAATATGATATGTGTTTTCCATGTATTAAAGGGGATACC
Downstream sequence
TATCCTTTTTAATATATCCTCTCTCATCTCTAttgaggtataacttacatataataaagcatagatatattaagtgtttctatgagttttgacaattgca
Target sequence
CTCCTAATATGATATGTGTTTTCCATGTATTAAAGGGGATACC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate