Basic Information
VIS ID
TVIS30014668
Fusion event
HIV-FAM107B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
14761229/14719230 (Hg38)
End
14761180/14719230 (Hg38)
Orient
-
Location type
Intronic
Target gene
FAM107B
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-3942-3p ; hsa-mir-759 ; hsa-mir-5197-3p ; hsa-mir-6882-5p ; hsa-mir-6507-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-6507-5p ; hsa-mir-8485 ; hsa-mir-1183 ; hsa-mir-3607-3p ; hsa-mir-4311
Nearest miRNA
hsa-mir-1265/Upstream/282569; hsa-mir-107/Downstream/3125877;
Nearest TSS
ENST00000439456/Upstream/66488; ENST00000493178/Downstream/55475;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/114524, chr10-CpG: 125/Downstream/118540
Upstream sequence
AGCTGTCAGACCATAGGCTTAGAGCAGGATCCGAGGCTCACTGATTTTCAGTTCACTGGACTAAGCCTGCCCAAATAACACACACTCAGGCCTGGGTTCG
Downstream sequence
GGAGTCAGAGTTCCAGCCAGGGACGCATTCTCTCCTGGCCCTATTTTCTTGCCTCTAAAATAAGAATCCTGACCTACTTCATTGGCCTGTCCTCGGGGAA
Target sequence
TTCACTGGACTAAGCCTGCCCAAATAACACACACTCAGGCCTGGGTTCG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate