Basic Information
VIS ID
TVIS30014671
Fusion event
HIV-TRDMT1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
17225938/17183939 (Hg38)
End
17225851/17183939 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRDMT1
miRNAs that regulate target gene
hsa-mir-1227-3p ; hsa-mir-648 ; hsa-mir-595 ; hsa-mir-5692a
Nearest miRNA
hsa-mir-1265/Upstream/2747278; hsa-mir-107/Downstream/661168;
Nearest TSS
ENST00000439456/Upstream/9279; ENST00000497849/Downstream/16628;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/365963, chr10-CpG: 49/Downstream/17366
Upstream sequence
TCAGACAAGAAAGGTTTGGCTCTTTTCTCAAGGCATGCCAATTGTGCTGTGACCTGTCACAGGCACATACACACCAGTAAACAATTATAACTCATTATAA
Downstream sequence
TTACAACAATTGTAACTCAGTGCATTATTTTACCTGCTAACTCAACAATAATCAAAAGAAAAACTAAAAATTAAACTACCTTATGAAAGTCTTCTAAAGA
Target sequence
GTTTGGCTCTTTTCTCAAGGCATGCCAATTGTGCTGTGACCTGTCACAGGCACATACACACCAGTAAACAATTATAACTCATTATAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate