Basic Information
VIS ID
TVIS30014684
Fusion event
HIV-NCOA4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
51575520/46020300 (Hg38)
End
51575395/46020300 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
NCOA4
miRNAs that regulate target gene
hsa-mir-93-3p ; hsa-mir-484 ; hsa-mir-365a-3p ; hsa-mir-3185 ; hsa-mir-3668 ; hsa-mir-4682 ; hsa-mir-6507-5p ; hsa-mir-218-5p ; hsa-mir-1185-1-3p ; hsa-mir-1185-2-3p ; hsa-mir-203a-3p ; hsa-mir-4777-3p ; hsa-mir-4635 ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-5692a ; hsa-mir-8077 ; hsa-mir-1827 ; hsa-mir-2682-5p ; hsa-mir-34b-5p ; hsa-mir-3653-3p ; hsa-mir-3658 ; hsa-mir-3973 ; hsa-mir-449c-5p ; hsa-mir-520g-3p ; hsa-mir-520h ; hsa-mir-548au-3p ; hsa-mir-607 ; hsa-mir-633
Nearest miRNA
hsa-mir-1265/Upstream/856212; hsa-mir-107/Downstream/2965212;
Nearest TSS
ENST00000439456/Upstream/763; ENST00000610892/Downstream/3155;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/47506, chr10-CpG: 42/Downstream/2901
Nearest cancer related gene
NCOA4(TSG, No orient, 0)
Upstream sequence
catataatatctcactttaaccttactgcagcccctctgtagcaaccatccttgtctccctttttcctgaggaagttgaggcccagagagattatgttac
Downstream sequence
tagctcaggggtctcaagcttggagacacagccataactcaggtttgtcagactccagagtgacctcttaacggtcatgctTGCTACTCTGGCTCTTGAA
Target sequence
aggtgctaggctaagtgccggtagacatataatatctcactttaaccttactgcagcccctctgtagcaaccatccttgtctccctttttcctgaggaagttgaggcccagagagattatgttac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate