Basic Information
VIS ID
TVIS30014691
Fusion event
HIV-HERC4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
69745276/67985519 (Hg38)
End
69745232/67985519 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
HERC4
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-222-3p ; hsa-mir-30c-5p
Nearest miRNA
hsa-mir-1265/Upstream/582109; hsa-mir-107/Downstream/3805228;
Nearest TSS
ENST00000439456/Upstream/28658; ENST00000373675/Downstream/4722;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/100099, chr10-CpG: 72/Downstream/89137
Upstream sequence
ACCTATATAAGTTTGATTATAACACTTTTATTTCACATTTTAATTAAAGTTTAGTATTCTTGCTTAAAAACCTCAGTTCAAGGGTGGTTATGGTGAGTAT
Downstream sequence
GTTTTATCTGTTTGGTTTTATTTAAGGGTTCTACATAAAATAGTTTGAAAATCACTGATTTAGATCAGCACAAATATGTAGCGACTAGGCTAGACAGACC
Target sequence
TTCTTGCTTAAAAACCTCAGTTCAAGGGTGGTTATGGTGAGTAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate