Basic Information
VIS ID
TVIS30014693
Fusion event
HIV-HNRNPH3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
70093547/68333790 (Hg38)
End
70093508/68333790 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
HNRNPH3
miRNAs that regulate target gene
hsa-mir-769-3p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-1265/Upstream/930380; hsa-mir-107/Downstream/3456957;
Nearest TSS
ENST00000439456/Upstream/741; ENST00000490442/Downstream/3016;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/974, chr10-CpG: 116/Downstream/72659
Upstream sequence
ATTGAAGACAGTACAAAAGGGAGGAGAAAGGCCTGAGAGTAAGAATTTCTGATAATTCATGTAAAACTTTATAAGAATATTGTTACCTACTTTTCCAGCT
Downstream sequence
CTAAAAACAAAAACTTATTATTATTGAAGATGTTCAGTGATGCTTTCTCAAGATTGCCAAGGAAAAGTTTACGAAAATCTTACCTTGAAACAGTAGGTTT
Target sequence
TAAAACTTTATAAGAATATTGTTACCTACTTTTCCAGCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate