Basic Information
VIS ID
TVIS30014702
Fusion event
HIV-EXOC6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.33
Reference genome
GRCh37/hg19
Start
94687083/92927326 (Hg38)
End
94687024/92927326 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
EXOC6
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-31-5p ; hsa-mir-4668-3p ; hsa-mir-6739-3p ; hsa-mir-6853-3p ; hsa-mir-1206
Nearest miRNA
hsa-mir-107/Upstream/3334499; hsa-mir-1287/Downstream/3136989;
Nearest TSS
ENST00000439456/Upstream/17842; ENST00000458552/Downstream/1048;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/78044, chr10-CpG: 255/Downstream/132943
Upstream sequence
CCTTAGATGATTAGGGAAATGGTTCTCAACCTTTCCTTCTGATGTTGGATGGGTTCTCTTTAAACAGTGAAGAAGACAGAGGGGATTGAGGTATAGTAAT
Downstream sequence
TAATTTATTTTTTCAGttattcacttacctaatatttattgagtgccttctgcatgccaagcattcttctaagtgatagggatacagtgatgagctagat
Target sequence
ATGTTGGATGGGTTCTCTTTAAACAGTGAAGAAGACAGAGGGGATTGAGGTATAGTAAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate