Basic Information
VIS ID
TVIS30014703
Fusion event
HIV-OGA integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
103550647/101790890 (Hg38)
End
103550706/101790890 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
OGA
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-30c-5p ; hsa-mir-17-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p
Nearest miRNA
hsa-mir-107/Upstream/189393; hsa-mir-1307/Downstream/645622;
Nearest TSS
ENST00000439456/Upstream/2925; ENST00000412353/Downstream/563;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/7357, chr10-CpG: 68/Downstream/26747
Upstream sequence
ATGTATCTATGTACTTTTCCATTTTAGTAAGTACtttaataaaaaataaaaataaataaataaaaaaGACCATTACCATAGTATAATTCTTAACCTTTGT
Downstream sequence
GAAGGGGATCCAGGAAATTTTACATTTTTTAATAAAGGGGGTCACATCTACAGTGCCCAAGGCATAACCACATATGCCATCTTCATCTTCTAGGACAAAG
Target sequence
ATTACCTCAGCCTCAGAGAGTTCCTTGTCACCATTTGGCTTGGTATACTTCTCCTGCAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate