Basic Information
VIS ID
TVIS30014706
Fusion event
HIV-GBF1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
104043452/102283695 (Hg38)
End
104043479/102283695 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
GBF1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-7-5p ; hsa-let-7f-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-485-5p ; hsa-mir-377-3p ; hsa-mir-485-3p
Nearest miRNA
hsa-mir-107/Upstream/682198; hsa-mir-1307/Downstream/152817;
Nearest TSS
ENST00000439456/Upstream/38163; ENST00000476019/Downstream/75404;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/37860, chr10-CpG: 146/Downstream/110277
Upstream sequence
AATACTAGAGGATAGACCTCATACTCTGAAAATGCTTTTGCCTCAACAATTTGAAAGAGAAATATGAAAGACAAAGTGACAATATGAAGAATGACTATTC
Downstream sequence
TGTTGGCAAGTTTTAACCTGTAGGTAGGGGAAAAACGTGGGAGGATCTCTTATTCAGAATGCAAAACAGGAGACAGTGAAGTACCTGTGTTTCCAAAGAA
Target sequence
AAAGTGCTTCTACCAGTAAGTCTTGTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate