Basic Information
VIS ID
TVIS30014707
Fusion event
HIV-SUFU integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
104291288/102531531 (Hg38)
End
104291257/102531531 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SUFU
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-378a-5p ; hsa-mir-93-3p ; hsa-mir-214-3p ; hsa-mir-181a-2-3p ; hsa-mir-3914 ; hsa-mir-4252 ; hsa-mir-6719-3p ; hsa-mir-6788-3p ; hsa-mir-6840-3p ; hsa-mir-873-5p ; hsa-mir-888-3p
Nearest miRNA
hsa-mir-107/Upstream/94947; hsa-mir-1307/Downstream/862722;
Nearest TSS
ENST00000439456/Upstream/27452; ENST00000471000/Downstream/59278;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/27133, chr10-CpG: 321/Downstream/110533
Nearest cancer related gene
SUFU(TSG, No orient, 0)
Upstream sequence
AACTGGCTTTGCTGGACAGGTCACCTTTCTTGTTGAGCTGATGCCCATTCCTTTGTTCGGCTGCTTTCACTGAGCACTCCTGTGCCAGTCAGTGGGGTGT
Downstream sequence
ACAAAGGGGTAAATCCTGTCCTGATGGGAGAGATAGGCAGCTGCAATACAGCAAGGAGAGTCCTGTGATGGAGGTTTGCACAGGGGTAAGGAAGAAGTGA
Target sequence
CTGAGCACTCCTGTGCCAGTCAGTGGGGTGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate