Basic Information
VIS ID
TVIS30014709
Fusion event
HIV-SLK integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
105732896/103973138 (Hg38)
End
105732827/103973138 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SLK
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-let-7c-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-107/Upstream/578737; hsa-mir-202/Downstream/74951;
Nearest TSS
ENST00000439456/Upstream/5937; ENST00000474260/Downstream/35060;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/5470, chr10-CpG: 46/Downstream/148553
Upstream sequence
aatttgttagttttttcctttacagttgatgctttttgtgttatgtttaagacatttcttcctaatgtgtgatcatgaagataatcttctatattatctt
Downstream sequence
ctaaaagctttatgattttgcttttctttaacaattagatctataatctacctagaatagatgtttgtaaatggtatgaggtaggggtccagtttcattt
Target sequence
ctttttgtgttatgtttaagacatttcttcctaatgtgtgatcatgaagataatcttctatattatctt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate