Basic Information
VIS ID
TVIS30014721
Fusion event
HIV-SIRT3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
220871/220871 (Hg38)
End
220918/220871 (Hg38)
Orient
+
Location type
Intronic
Target gene
SIRT3
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-1247-3p ; hsa-mir-302a-5p ; hsa-mir-3160-3p ; hsa-mir-4487 ; hsa-mir-455-3p ; hsa-mir-495-5p ; hsa-mir-558 ; hsa-mir-5694 ; hsa-mir-6087 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-6771-3p
Nearest miRNA
hsa-mir-6743/Upstream/11465; hsa-let-7a-2/Downstream/347218;
Nearest TSS
ENST00000527297/Upstream/7422; ENST00000534590/Downstream/9821;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/11646, chr11-CpG: 101/Downstream/15047
Nearest cancer related gene
SIRT3(TSG, No orient, 0)
Upstream sequence
GCATTTACCCTTCAGGAGTACTTGCATGGGTAGATAAGGATGACACACAGGGATATTCACCGGAAGGCAAGTTCTCAGTATTTATCAGCATTTACCCTTC
Downstream sequence
TACAGCATTTACCCTTCAGGAGTACTTGCATGGGTAGATAAGGATGACACACAGGGATATTCACCGGAAGGCAAGTTCTCAGTATTTATCAGCATTTACC
Target sequence
CAGAGTACTTGCATGGGTAGATAAGGATGATACACAGGGATATTCAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate