VISDB - VIS Detail

Basic Information

VIS ID

TVIS30014734

Fusion event

HIV-IPO7 integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr11

Cytoband

p15.4

Reference genome

GRCh37/hg19

Start

9432282/9410735 (Hg38)

End

9432561/9410735 (Hg38)

Orient

Location type

Intronic

Target gene

IPO7

miRNAs that regulate target gene

hsa-mir-9-5p ; hsa-mir-16-5p ; hsa-mir-1226-3p ; hsa-mir-106b-5p ; hsa-mir-204-5p ; hsa-mir-92a-3p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-5696 ; hsa-mir-340-5p ; hsa-mir-513a-3p ; hsa-mir-582-5p ; hsa-mir-1229-3p ; hsa-mir-513c-3p ; hsa-mir-3606-3p ; hsa-mir-6511a-3p ; hsa-mir-6511b-3p ; hsa-mir-6784-3p ; hsa-mir-6862-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-579-3p ; hsa-mir-664b-3p ; hsa-mir-203a-3p ; hsa-mir-449c-3p ; hsa-mir-302f ; hsa-mir-5000-5p ; hsa-mir-6853-3p ; hsa-mir-8086 ; hsa-mir-205-5p ; hsa-mir-2681-5p ; hsa-mir-101-3p ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-455-5p ; hsa-mir-302b-5p ; hsa-mir-302d-5p ; hsa-mir-331-5p ; hsa-mir-33a-3p ; hsa-mir-411-5p ; hsa-mir-4278 ; hsa-mir-4450 ; hsa-mir-4678 ; hsa-mir-548ag ; hsa-mir-548ai ; hsa-mir-548ba ; hsa-mir-548m ; hsa-mir-570-5p ; hsa-mir-6783-5p ; hsa-mir-6789-5p ; hsa-mir-6824-5p ; hsa-mir-7-5p

Nearest miRNA

hsa-mir-210/Upstream/320356; hsa-let-7a-2/Downstream/1097535;

Nearest TSS

ENST00000527297/Upstream/666; ENST00000531235/Downstream/9544;

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/25580, chr11-CpG: 86/Downstream/49827

Upstream sequence

AGAAAAAAAGATTTTAGGCCAAGTGATTATTTTAGATCTTGTTTTAGGGATCAGGAAAAAAAGATCTAACCTAGAAAGTTGAGGTATAGCACTGAGAGTG

Downstream sequence

CTGGTGTTTTCTTGTGTTCCCACCAGCTACCCATCTTCCTGCTAAGGAATGTTCCAGCTGTTACAGTTCTGGTAAGTGAGTGACTAAAATTGGAGAGAAT

Target sequence

GTAAGCCACATGTTGAAGGAGTTTTTTAAGTCTATAGTTGATAGGCACTTGAAAAGGTTTGATGGGATATTACGAGGAAGGCATAAGGAAGACTTTTATACCATGATCGTGACTTTATTGCCAGTCTTAACAGCTACACAGATGCCATTGTGACCCCTCTAATTCTGGGACTTGCAGTTAGCCTCCAATACCCTCTTTGGGTCCCATCTCAAAGTGGCTGATGAACTGCTGCTTTTATTCTCTGAGCAGGAGAGA

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.