Basic Information
VIS ID
TVIS30014740
Fusion event
HIV-TSG101 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
18515986/18494439 (Hg38)
End
18516099/18494439 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
TSG101
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-33a-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-331-3p ; hsa-mir-106b-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-6847-5p ; hsa-mir-4676-5p ; hsa-mir-575 ; hsa-mir-4797-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-548e-5p ; hsa-mir-106a-5p ; hsa-mir-526b-3p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-181d-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-210/Upstream/106579; hsa-let-7a-2/Downstream/1080871;
Nearest TSS
ENST00000527297/Upstream/10378; ENST00000511927/Downstream/20404;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/38230, chr11-CpG: 52/Downstream/32074
Nearest cancer related gene
TSG101(TSG, No orient, 0)
Upstream sequence
AAAATTAACGTTTTGTGAAAAGACTAATTTAAGAATCTATTATGTTAGAGGTATTCTATAGGAATAACGACAGGAAGCCAAATGAATCAGCTTCTCCTAC
Downstream sequence
CATTATTGCTTTGGCAGAAAAGGATTTAACATTTAGCAGACTAAACTCTCAGCATTTAAATTTCACTCATGACTCACTGACTGTCCAGGATTGGAAGAAA
Target sequence
CTTTCCTTTACTAACAAAATAAAAATCATTTGTTAACTTACACAATAGCTTTTTTAAAAGCTTTCAAATCTATCATTATTGCTTTGAATTTCTGTTATCATTATTTCTGTTAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate