Basic Information
VIS ID
TVIS30014741
Fusion event
HIV-PRMT3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
20415724/20394178 (Hg38)
End
20415842/20394178 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
PRMT3
miRNAs that regulate target gene
hsa-mir-361-3p ; hsa-mir-106b-5p ; hsa-mir-1260b ; hsa-mir-5591-3p ; hsa-mir-5698 ; hsa-mir-891a-3p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-564 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-5693 ; hsa-mir-4482-5p ; hsa-mir-3130-5p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-5704 ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-4495 ; hsa-mir-1295b-3p ; hsa-mir-15a-3p ; hsa-mir-4717-5p
Nearest miRNA
hsa-mir-210/Upstream/634095; hsa-let-7a-2/Downstream/3024927;
Nearest TSS
ENST00000527297/Upstream/6431; ENST00000529592/Downstream/11268;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/5943, chr11-CpG: 123/Downstream/202473
Upstream sequence
TTGGCTTAGCTATTTTGTCCTAATTCCAAGGACGTGTCTTCACAACTAAAAAATGAATAGGAATTTTTACGAAGTCACATTTCTTCCAGTGCTATCCTGA
Downstream sequence
GAAGTGAAATTAAAATTAAATACTAGGAATTAGGATATTTAATAATATCAGCAATAAGACTTTAGTGTATAGATTTCACTCCACCTTGCCCAGGATGAAA
Target sequence
GGGGAAAATGTAATATTTGCACTGCTCACTGCCTTAAGTTGATCCGAAAGTTAGATCAGTAAATGGACACTGATTTTGTGAAATTCACTAACTACATATATTAACTTCTCTTTGTAGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate