Basic Information
VIS ID
TVIS30014763
Fusion event
HIV-TAF6L integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
62553636/62786164 (Hg38)
End
62553528/62786164 (Hg38)
Orient
-
Location type
Intronic
Target gene
TAF6L
miRNAs that regulate target gene
hsa-mir-106b-5p
Nearest miRNA
hsa-mir-129-2/Upstream/219093; hsa-let-7a-2/Downstream/3651;
Nearest TSS
ENST00000527297/Upstream/4438; ENST00000526546/Downstream/621;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/14314, chr11-CpG: 138/Downstream/430
Upstream sequence
ctttattcccaatgcctagcttaggtatacagtaggttccaaataaatatatggttgaatATGCCAATCAGGGAATTTAGGAGGATTGAGCCCTGTCTAG
Downstream sequence
GATCAGAGATAAAGGTAGGTCTTTCATGGGAAAGGGTCCTTGAGAGGGAATAAGTATCAAAGACATGCTAACTGTATTCCTTCTCTTCCTTCCAGGCAGT
Target sequence
taccttatctttattcccaatgcctagcttaggtatacagtaggttccaaataaatatatggttgaatATGCCAATCAGGGAATTTAGGAGGATTGAGCCCTGTCTAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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