Basic Information
VIS ID
TVIS30014770
Fusion event
HIV-EHD1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64640757/64873285 (Hg38)
End
64640797/64873285 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
EHD1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-6739-5p ; hsa-mir-670-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-4329 ; hsa-mir-6859-3p ; hsa-mir-7113-3p ; hsa-mir-4324 ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-4732-3p ; hsa-mir-125a-5p ; hsa-mir-345-3p ; hsa-mir-645 ; hsa-mir-1226-3p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-26a-5p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-1237/Upstream/504582; hsa-let-7a-2/Downstream/5238;
Nearest TSS
ENST00000527297/Upstream/13240; ENST00000413292/Downstream/2381;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/18511, chr11-CpG: 124/Downstream/4672
Upstream sequence
CAGGAGTTTACACAATTGGAATGGGCACGGTGCACTACTGCATAGCAAGAAGGCCTCAGCCAGGGAGGCTGCTGTCAACCTCTAAGCAAATGTAAGCAAA
Downstream sequence
TTTTGCTTGGCTCTCTCTCAGTCCTGCTGGACGTGTGAGGAATGTATATGGCTTTGGGGGGCAAAGGCTGTTAAACACAGACTAAAGCTAATAAGCTCTG
Target sequence
TTTCCACCAGCCCGTTTCATGAATTTCTACCAGCTTCTCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate