Basic Information
VIS ID
TVIS30014771
Fusion event
HIV-ZFPL1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64853544/65086072 (Hg38)
End
64853369/65086072 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
ZFPL1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-10392/Upstream/67502; hsa-let-7a-2/Downstream/43844;
Nearest TSS
ENST00000527297/Upstream/785; ENST00000528123/Downstream/267;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1716, chr11-CpG: 31/Downstream/10154
Upstream sequence
AGATATAGGGAATGCCACTTGTGTTTGATTATGTGCTTATAAGGACATGTACATTTGTGCCCAGGGATGTGTACATGTATATGTGTGCCTGTGTGTGTAT
Downstream sequence
CGAGGAACCTTTTCTGAAACTGTTCATTATTAGCCATTAGCCCAAAGAATATGATGAGTGCAGGCCCAGAGAGGACTCATTGAAAGGACTGAAAGGGGAG
Target sequence
ATGGTTGAGGGTGCCTGTTAGCAAACCTGTGAGTGTATAGATGTGTATGTGTGAGGGCTCCTGTACCCATAGTGTAGATATAGGGAATGCCACTTGTGTTTGATTATGTGCTTATAAGGACATGTACATTTGTGCCCAGGGATGTGTACATGTATATGTGTGCCTGTGTGTGTAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate