Basic Information
VIS ID
TVIS30014773
Fusion event
HIV-CAPN1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64963533/65196062 (Hg38)
End
64963607/65196062 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
CAPN1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-34a-5p ; hsa-mir-140-5p ; hsa-mir-487a-5p ; hsa-mir-487b-5p ; hsa-mir-1205 ; hsa-mir-4460 ; hsa-mir-203b-5p ; hsa-mir-6718-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-6809-5p ; hsa-mir-4708-3p ; hsa-mir-17-3p ; hsa-mir-1184 ; hsa-mir-3158-5p ; hsa-mir-4742-5p ; hsa-mir-1249-5p ; hsa-mir-1321 ; hsa-mir-1343-5p ; hsa-mir-140-3p ; hsa-mir-149-3p ; hsa-mir-151a-5p ; hsa-mir-151b ; hsa-mir-3173-3p ; hsa-mir-3177-3p ; hsa-mir-3188 ; hsa-mir-4419a ; hsa-mir-4445-3p ; hsa-mir-4493 ; hsa-mir-4510 ; hsa-mir-4728-5p ; hsa-mir-4739 ; hsa-mir-4747-5p ; hsa-mir-4756-5p ; hsa-mir-4779 ; hsa-mir-5196-5p ; hsa-mir-548al ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6785-5p ; hsa-mir-6797-5p ; hsa-mir-6883-5p ; hsa-mir-6891-5p ; hsa-mir-7150 ; hsa-mir-939-5p ; hsa-mir-9500
Nearest miRNA
hsa-mir-10392/Upstream/66084; hsa-let-7a-2/Downstream/248396;
Nearest TSS
ENST00000527297/Upstream/7817; ENST00000530495/Downstream/7310;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/11498, chr11-CpG: 26/Downstream/8652
Upstream sequence
ttctttctaggaatttgttctttttgtctatattatctaatttattatcatataattgtctatagtgtttccttgtaatctttttatttttgttaggctg
Downstream sequence
aagaattgtcaattttgttgagcttttcaaagaactattggttttattgatttttctttattgtttattctctatttcatgtatttggactttaatcttc
Target sequence
gtagtgatgtccctctttaattcctgattttagtaatttgagtcctctgtcttttctcctgtttaggccaggta
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate