Basic Information
VIS ID
TVIS30014777
Fusion event
HIV-NEAT1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
65204226/65436755 (Hg38)
End
65204337/65436755 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
NEAT1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-449b-5p
Nearest miRNA
hsa-mir-10392/Upstream/306777; hsa-let-7a-2/Downstream/7703;
Nearest TSS
ENST00000527297/Upstream/11204; ENST00000620902/Downstream/51381;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/13168, chr11-CpG: 26/Downstream/18264
Nearby gene
MIR612(No orient, 7702)
Nearest cancer related gene
NEAT1(OG, No orient, 0)
Upstream sequence
agtacatctaggtaagcaccgcatatctgtattcatgtctgccttggtcttttcaacatctgtgtggtagccgtgtttgaattacccattccctttttgg
Downstream sequence
ctcaggaggaattctgggcacagcatgtgtaaatttctaaatatgatggacacccccagcttccacctcaaggaggttggtcccattgacatttccccac
Target sequence
ggaaccattaagttgtttcagcaatttttactgtagataaggctataccgcatatctgtgtacatgggtttttatgtacatgggcaagtatatctgtgagagaaaagtttc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate