Basic Information
VIS ID
TVIS30014781
Fusion event
HIV-PCNX3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
65400017/65632546 (Hg38)
End
65399708/65632546 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
PCNX3
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-323a-5p
Nearest miRNA
hsa-mir-10392/Upstream/187989; hsa-let-7a-2/Downstream/3764;
Nearest TSS
ENST00000527297/Upstream/2135; ENST00000526137/Downstream/5551;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/16160, chr11-CpG: 33/Downstream/2718
Upstream sequence
AGTTACTGGGCTCTCAGACCTGCTTCTGCAGCTGGGAAGGGCTACAAGAGCAGGAAAAGGCACCGTGGCTTGAGGCTGCACGGAGTCTGGGCAGTGCTTC
Downstream sequence
CCGGGAAGTACCTTGGGCAGAGCCCAGCTCGCAGTGAGCGCTCACAGGCGGAGCGGCTGCTGGTATTGCCCCCCGTCTTCATTTTCTTCCTAAGATGACC
Target sequence
CTGGGGTGGCTCCGCTGAGGATGTGGACTGAGGGTGAAGCTTGGAAGGACAAGTCAGGGCTGCCAGGGGTGGGGCGGGGGGAGGCGGGTGTGCTGGGGAGCCTGGTGCATCTGGGGAAGTGTCCCAGCTGCAGGGATAGGTCCTTTCCAGCCTTCGAGGTTGGCCAGTCGAGGCGGAGCCCCTCCCGTTAGCTTTGCCCTTCCCGTGGGAGTTACTGGGCTCTCAGACCTGCTTCTGCAGCTGGGAAGGGCTACA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate