Basic Information
VIS ID
TVIS30014782
Fusion event
HIV-SIPA1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
65414265/65646794 (Hg38)
End
65414291/65646794 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA11H
Target gene
SIPA1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-6779-5p ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-7704 ; hsa-mir-6825-5p ; hsa-mir-6799-5p ; hsa-mir-6785-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-766-5p ; hsa-mir-661 ; hsa-mir-6087 ; hsa-mir-3192-5p ; hsa-mir-542-5p ; hsa-mir-6777-5p ; hsa-mir-6889-5p
Nearest miRNA
hsa-mir-10392/Upstream/10425; hsa-let-7a-2/Downstream/2398;
Nearest TSS
ENST00000527297/Upstream/983; ENST00000531339/Downstream/572;
Nearest CpG islands
chr11-CpG: 148/Target, None/Upstream, None/Downstream
Upstream sequence
GCTTCGGCCTGCCCTCCCTGGGTGGGAGGCGCCGGGCGGCCCCTCGGGGCCCAGGCGCCGAGCTGCAGGCAGCGGGCTCACTGGTGTGGGGAGTgcgcgc
Downstream sequence
gggcTCAGGCGAGCGGCCCCGAAGGCATCGAGGTGCCCTGCCTGCTGGGCATCTCGGCCGAGGCTCTGGTGCTGGTGGCGCCGCGCGACGGCCGCGTAGT
Target sequence
ggcgcccggggcgcgggtcgccgccg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate