Basic Information
VIS ID
TVIS30014786
Fusion event
HIV-PACS1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
65852765/66085294 (Hg38)
End
65852828/66085294 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
PACS1
miRNAs that regulate target gene
hsa-mir-324-5p ; hsa-mir-320a ; hsa-mir-218-5p ; hsa-mir-6869-5p ; hsa-mir-526b-5p ; hsa-mir-431-5p ; hsa-mir-4711-5p ; hsa-mir-935 ; hsa-mir-3662 ; hsa-mir-6513-5p ; hsa-mir-599 ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-3145-3p ; hsa-mir-610 ; hsa-mir-3614-5p ; hsa-mir-4461 ; hsa-mir-6079 ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-9-5p ; hsa-mir-8485 ; hsa-mir-1200 ; hsa-mir-4284 ; hsa-mir-4772-3p ; hsa-mir-4682 ; hsa-mir-3653-5p ; hsa-mir-1304-3p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-660-3p ; hsa-mir-6890-3p ; hsa-mir-1306-5p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-2861 ; hsa-mir-3134 ; hsa-mir-449b-3p ; hsa-mir-4534 ; hsa-mir-602 ; hsa-mir-6081 ; hsa-mir-6749-5p ; hsa-mir-8082
Nearest miRNA
hsa-mir-10392/Upstream/436041; hsa-let-7a-2/Downstream/849140;
Nearest TSS
ENST00000527297/Upstream/1321; ENST00000527380/Downstream/15469;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/14116, chr11-CpG: 120/Downstream/172145
Upstream sequence
TAAGAGTTTTTTTCTTTTTTGAAAGACTGGTTTGCTGTATCAGACAGCCTGTCTGCACTTCCTAGGAGCTGCTCTGTGAGGAGGAATCCTGCTGCAGAAT
Downstream sequence
CCCTTTGCTCAAGATTGCCAAACTGGATCTTACTGTTTTATAAAGGCAAAGGACTCAGAGTTTGCAGTTTGAACTCCTATTTCCCTCTCGTTCTGCTCAT
Target sequence
GATCTAATTTGTGTAATCTTGAAGGTGGAGCTATTTTTGAAAGAGAACAGAAAAATAATGGAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate