Basic Information
VIS ID
TVIS30014790
Fusion event
HIV-RBM4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
66409776/66642305 (Hg38)
End
66409580/66642305 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
RBM4
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-let-7e-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-10392/Upstream/993052; hsa-let-7a-2/Downstream/292129;
Nearest TSS
ENST00000527297/Upstream/3370; ENST00000515838/Downstream/1445;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/3085, chr11-CpG: 47/Downstream/1149
Nearest cancer related gene
RBM4(TSG, No orient, 0)
Upstream sequence
AATTTTGCAAGGAAAATTGTGTGTTTACCACTTTCTCTAATGTTAGAGGATCCATTTGTTGACTCTCCCTTGCTTTTGACCATTTACTCCTTTGACAGGT
Downstream sequence
GTATGTTTAGGTGCATCATAACCAATTGCATTGGGAAGTTTTTGCAGGATTTGGATCTCTTCTGAATTTTGCTTACCAGTAAGCTGGTAGATCATGTTAG
Target sequence
CAACCTAAACTTCCAGCTGTGTAGACCTCCTTGATATTTTGTTCCTTCCACCCCCGTTTCCCTATTGTGTTTTCTGGTCTCCCAGAATCTAACATTAATTTTGCAAGGAAAATTGTGTGTTTACCACTTTCTCTAATGTTAGAGGATCCATTTGTTGACTCTCCCTTGCTTTTGACCATTTACTCCTTTGACAGGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate