Basic Information
VIS ID
TVIS30014795
Fusion event
HIV-C11orf80 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
66559737/66792266 (Hg38)
End
66559789/66792266 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
C11orf80
miRNAs that regulate target gene
hsa-mir-6828-5p ; hsa-mir-7108-3p
Nearest miRNA
hsa-mir-10392/Upstream/1143013; hsa-let-7a-2/Downstream/142168;
Nearest TSS
ENST00000527297/Upstream/4106; ENST00000527352/Downstream/3631;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/29841, chr11-CpG: 91/Downstream/50629
Upstream sequence
GGGGTTAGTTGTGTTGTATTAATTATCCTCTCTGACCTGACATTAGTCACTTTATCCTAACTCTGGGATAGGTGTCGGTCCTTCTGctgtattcctttag
Downstream sequence
actgaactgtgaactcttctaattctgagattgtcttatttatttttataagcccaggtacataataagccacattaatattttatgagtgagtaaatGC
Target sequence
cacctcatttatctaaatttcacattgtcatataaattagtctgtctcatct
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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