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Viral Integration Site DataBase
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TVIS30014797
Basic Information
VIS ID
TVIS30014797
Fusion event
HIV-KDM2A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
66984976/67217505 (Hg38)
End
66984935/67217505 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
KDM2A
miRNAs that regulate target gene
hsa-mir-124-3p
;
hsa-mir-16-5p
;
hsa-mir-1226-3p
;
hsa-mir-296-3p
;
hsa-mir-769-5p
;
hsa-mir-92b-3p
;
hsa-mir-29b-3p
;
hsa-mir-137
;
hsa-let-7i-3p
;
hsa-mir-106b-3p
;
hsa-mir-1273h-5p
;
hsa-mir-1294
;
hsa-mir-1539
;
hsa-mir-185-5p
;
hsa-mir-30b-3p
;
hsa-mir-30c-1-3p
;
hsa-mir-30c-2-3p
;
hsa-mir-3122
;
hsa-mir-3134
;
hsa-mir-3150b-3p
;
hsa-mir-3654
;
hsa-mir-3689a-3p
;
hsa-mir-3689b-3p
;
hsa-mir-3689c
;
hsa-mir-377-5p
;
hsa-mir-3913-5p
;
hsa-mir-3939
;
hsa-mir-4306
;
hsa-mir-4464
;
hsa-mir-4477b
;
hsa-mir-450a-1-3p
;
hsa-mir-4534
;
hsa-mir-4644
;
hsa-mir-4683
;
hsa-mir-4693-3p
;
hsa-mir-4695-3p
;
hsa-mir-4748
;
hsa-mir-4784
;
hsa-mir-4802-5p
;
hsa-mir-5192
;
hsa-mir-574-5p
;
hsa-mir-6086
;
hsa-mir-6513-5p
;
hsa-mir-655-5p
;
hsa-mir-6731-5p
;
hsa-mir-6740-5p
;
hsa-mir-6746-5p
;
hsa-mir-6779-5p
;
hsa-mir-6780a-5p
;
hsa-mir-6788-5p
;
hsa-mir-6878-5p
;
hsa-mir-6894-5p
;
hsa-mir-7154-3p
;
hsa-mir-765
;
hsa-mir-766-5p
;
hsa-mir-8082
;
hsa-mir-8085
;
hsa-mir-887-5p
Nearest miRNA
hsa-mir-10392/Upstream/171797; hsa-let-7a-2/Downstream/272740;
Nearest TSS
ENST00000527297/Upstream/1594;
ENST00000525379/Downstream/38;
Nearest CpG islands
None/Target,
chr11-CpG: 30/Upstream/97646
,
chr11-CpG: 17/Downstream/32631
Nearest cancer related gene
KDM2A
(OG, No orient, 0)
Upstream sequence
TACTACTTAGGACTCTGGAAGCCAGACAGAGTGTTTAAGGGACTGCCTAGGTAATGAGCTGAATGGTCCCTCTTCTCTCCGAGTCCTGGATGGTGTATAG
Downstream sequence
TCAAACCCAAGGGAAGCCTTAATGCTGTTGGATCAAGTGAAGGATAAGAAAGATCTACTGCCTTGGACCTTCTAGGGTTTACCACATAGTCAAGTTCTAT
Target sequence
TGAATGGTCCCTCTTCTCTCCGAGTCCTGGATGGTGTATAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT5
Sample type
PBMC
Age
44
Gender
Male
CpG Island Information
×
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