Basic Information
VIS ID
TVIS30014801
Fusion event
HIV-PITPNM1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
67270284/67502813 (Hg38)
End
67270498/67502813 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
PITPNM1
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-432-5p
Nearest miRNA
hsa-mir-10392/Upstream/12498; hsa-let-7a-2/Downstream/530051;
Nearest TSS
ENST00000527297/Upstream/185; ENST00000489040/Downstream/1439;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/7569, chr11-CpG: 149/Downstream/1375
Upstream sequence
TTTTTCTGTGGCCCAAGGGAGAGCAGGACAGGGAGCTCAGCCCCAGCTTAGCATCTGGGATCCCCAGCTCAGCCTGGTGTTCTACACAGCTCTGGGGCCC
Downstream sequence
ctcgtggaacttacattctagtggaaggagacagacaaaaggaaaaagcaaattatgtggtgtgttagaaggcgctaggtgctataggaaaagaaagcct
Target sequence
TGGTCCCAGCCTTTTCAACTCCCTGAAACCAGACCCCGCCCCACCAAAGCTCCCTGGGATCAGAATCACAGATGCAGCCCAGCCCCGCATGGGGTCTGCAACCCAGCACTCAGttgagtcattcaagtattcattgagtgtctgctccactccaggcagtgtttgggattatatcaattgagatatattgatgaatagaacaaagatccctgcc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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