Basic Information
VIS ID
TVIS30014803
Fusion event
HIV-RNF121 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71672116/71961070 (Hg38)
End
71672025/71961070 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
RNF121
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-92a-3p ; hsa-mir-4417 ; hsa-mir-6748-5p ; hsa-mir-654-5p ; hsa-mir-4483 ; hsa-mir-541-3p ; hsa-mir-1293 ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-4745-5p ; hsa-mir-4481 ; hsa-mir-6127 ; hsa-mir-7515 ; hsa-mir-3185 ; hsa-mir-9500 ; hsa-mir-3154 ; hsa-mir-6768-5p ; hsa-mir-3941 ; hsa-mir-521 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1252-5p ; hsa-mir-3688-5p ; hsa-mir-498 ; hsa-mir-891a-3p
Nearest miRNA
hsa-mir-10392/Upstream/487502; hsa-let-7a-2/Downstream/111158;
Nearest TSS
ENST00000527297/Upstream/3831; ENST00000525176/Downstream/22587;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/147263, chr11-CpG: 51/Downstream/119269
Upstream sequence
CCAGGCCACATGGAGGTGGAGAAAGACAATAACAATGAACTTTATGTATGAATGATGAATAGTGTATTGGCGAGTGTGTGTCTAAGGGTCAGGTGATTCA
Downstream sequence
GAGGGTGAAAAGGATAGAACATAAGACTATGTTCATAGGCAGAAAAGATAGGTTTTCCCTTCGAAACATTGTGGGACAGGTTCATGAAGGAGATAATCAT
Target sequence
ATGGAGGTGGAGAAAGACAATAACAATGAACTTTATGTATGAATGATGAATAGTGTATTGGCGAGTGTGTGTCTAAGGGTCAGGTGATTCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate