Basic Information
VIS ID
TVIS30014807
Fusion event
HIV-NUMA1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71778170/72067124 (Hg38)
End
71778049/72067124 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
NUMA1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1208 ; hsa-mir-1252-5p ; hsa-mir-1911-3p ; hsa-mir-1972 ; hsa-mir-211-3p ; hsa-mir-4466 ; hsa-mir-4767 ; hsa-mir-6721-5p ; hsa-mir-6753-5p ; hsa-mir-675-5p ; hsa-mir-6760-3p ; hsa-mir-6816-3p ; hsa-mir-7112-3p ; hsa-mir-7112-5p ; hsa-mir-7113-5p
Nearest miRNA
hsa-mir-10392/Upstream/593556; hsa-let-7a-2/Downstream/5104;
Nearest TSS
ENST00000527297/Upstream/24982; ENST00000537483/Downstream/2939;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/253317, chr11-CpG: 51/Downstream/13215
Upstream sequence
AAGATGACTATGTTTACACAATCCTAATTAAAACTAAAGGGCAATGAGGGAAAGAAGAGAAATAGGGAGATTAAGAGGTGTGGATTCTACAGGTCACCTC
Downstream sequence
CTCTTCTTAGTGAGCTTGCTAGGCACTAGGCTGGAAGATCTGAGCTACAAAGTAGCCTATTTTATCTTTGGGGTAGCCTGTAGGATCTAAGTATTGAAAA
Target sequence
TGCCACTTTAAGAGGACTGGCAAGATGACTATGTTTACACAATCCTAATTAAAACTAAAGGGCAATGAGGGAAAGAAGAGAAATAGGGAGATTAAGAGGTGTGGATTCTACAGGTCACCTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate