Basic Information
VIS ID
TVIS30014815
Fusion event
HIV-RAB6A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73426904/73715859 (Hg38)
End
73426846/73715859 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
RAB6A
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-186-5p ; hsa-mir-21-5p ; hsa-mir-324-5p ; hsa-mir-4668-5p ; hsa-mir-2053 ; hsa-mir-488-3p ; hsa-mir-4699-5p ; hsa-mir-382-5p ; hsa-mir-548an ; hsa-mir-195-3p
Nearest miRNA
hsa-mir-10392/Upstream/932267; hsa-let-7a-2/Downstream/683378;
Nearest TSS
ENST00000527297/Upstream/53506; ENST00000538624/Downstream/6490;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/54272, chr11-CpG: 112/Downstream/44371
Upstream sequence
AAGCTATTCAGTGCAACTACACAGTCTGGCTCAGCCACACAATTAAAAACCAACAACCAAAAAACAAAAATCCACACCACTGAATTATAATGAATGTTTT
Downstream sequence
ATAAGAAGACTACTAAGAAAAGAGTGTGCATTTAATCATTATGAACAATTTTTAAAGATAAGGTTTTTCCAAAATGGCTTGCTCTTTAACAAAACACTTT
Target sequence
TTAAAAACCAACAACCAAAAAACAAAAATCCACACCACTGAATTATAATGAATGTTTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate