Basic Information
VIS ID
TVIS30014816
Fusion event
HIV-PPME1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73914600/74203555 (Hg38)
End
73914565/74203555 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
PPME1
Nearest miRNA
hsa-mir-10392/Upstream/1419963; hsa-let-7a-2/Downstream/195682;
Nearest TSS
ENST00000527297/Upstream/32212; ENST00000535205/Downstream/27230;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/32028, chr11-CpG: 38/Downstream/107828
Upstream sequence
TGAATTTTGAAAAATCCTAAAATTTTTACTCTTAAATCTATGTTTGGATTTAAATACATTTTAAAATACTTATTTAAATGCATTTACATTATTATGTAAT
Downstream sequence
ACAATACATTAAATACATTTTTAATATGATACTTTGTGATGAACTCTTTATATCTTTAAGAGAAAATACCTTTGCTGTTTTCATTACTGACTTACATTTA
Target sequence
ATACTTATTTAAATGCATTTACATTATTATGTAAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate